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The construction of prototype tomographs and spectrometers of Electron Paramagnetic Resonance (EPR) and Proton Electron Double Resonance Imaging (PEDRI) using the modified method of continuous wave and rapid scan method for biomedical applications and supporting research on cancer therapies.
Project No. POIR.01.01.01-00-0025/15
The project regards the construction of prototype Electron Paramagnetic Resonance (EPR) equipped with an attachment for dual resonance imaging proton – electron (PEDRI) with a resonant frequency of 250MHz & 1GHz. These devices will provide information on the concentration of radicals and oxygen partial pressure and their changes over time in living objects. With their use it will be possible to monitor the effectiveness of cancer therapies depending on the instantaneous values of partial pressures of oxygen within the tumor tissue and identifying those moments where the treatment will be most effective. Combination of functional imaging (PO2 tomography EPR) with an anatomical (PEDRI tomography) will provide comprehensive knowledge of the study area. The project will also regard the construction of a prototype educational EPR tomograph and the spectrometer at a resonant frequencies of 250MHz&1GMHz.
The main objectives
- EPR scanner 250MHz (CW and RAPID detection)
- EPR scanner 1GHz (CW and RAPID detection)
- Training scanner EPR 250 MHz (CW detection)
- PEDRI extension
- Fast data acquisition
- High temporal resolution
Innovative pulse tomograph for spatial imaging of neurodegenerative changes based on electronic resonance technique
Project No. POiR.01.02.00-00-0077/18-00
The project relates to the development and preparation for the implementation of a specialized, innovative pulse tomograph for spatial imaging of neurodegenerative changes using the technique of electron paramagnetic resonance. Tomography developed within the project is designed to advance scientific development, aiming at final rescaling for clinical use and satisfying the needs of patients in the field of proper diagnostics of neurodegenerative diseases. The tomograph will allow to examine larger objects than in current technologies, in a much shorter and more precise way.
The main objectives
- Development of an innovative pulse technology that allows to compensate for the dead time of the scanner
- Impact of B1 field heterogeneity on the recorded signal
- Simultaneously increase the amplitude of the recorder EPR signal
- Device validation in real conditions and obtaining CE certification